WebDARZALEX is a CD38-directed cytolytic antibody indicated: • in combination with lenalidomide and dexamethasone, or bortezomib and dexamethasone, for the … WebAug 9, 2024 · CD38 is a transmembrane glycoprotein that functions both as a receptor and an ectoenzyme, playing key roles in the regulation of calcium signaling and …
Reference ID: 4016996 - Food and Drug Administration
WebCD38 is an effective target in some hematological malignancies such as multiple myeloma (MM). Daratumumab (Dara), a CD38-targeting antibody, can eliminate CD38 high immune suppressor cells and is regarded as a standard therapy for MM because of its outstanding clinical efficacy. WebAug 24, 2024 · The Food and Drug Administration (FDA) has approved daratumumab, a CD38-directed cytolytic antibody, in combination with carfilzomib, a proteasome … huggy wuggy x player lemon
Internet Explorer is no longer supported by this website.
WebIn conclusion, these data indicate that depletion of CD38-expressing cells could be a therapeutic mechanism for treating autoimmune diseases. SIGNIFICANCE STATEMENT: This study demonstrates that targeting CD38-expressing leukocytes with a cytolytic antibody can ameliorate autoimmune disease in cynomolgus monkeys. WebJun 26, 2024 · MCD38-Directed Monoclonal Antibodies in Action Against MM Cells13 CD38 expression also is thought to contribute to the immunosuppressive microenvironment. It is expressed on many... WebDARZALEX is a CD38-directed cytolytic antibody indicated for the treatment of adult patients with multiple myeloma: • in combination with lenalidomide and dexamethasone in newly diagnosed patients who are ineligible for autologous stem cell transplant and in patients with relapsed or refractory multiple myeloma who have received holiday in indian stock market