Gm-csf protein

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August undefined, 2024

WebGM-CSF is a proinflammatory cytokine with neuroprotective and angiogenic properties exhibited during in vivo models of cerebral ischemia . In vitro, GM-CSF promotes macrophage, neutrophil and eosinophil survival and activation . Of note, GM-CSF was shown to promote arteriogenesis in cardiovascular ischemic disease, thereby …

Recombinant mouse GM-CSF protein (Active) (ab259385) - Abcam

WebGM-CSF is a hematopoietic growth factor that stimulates the development of early erythroid megakaryocytic and eosinophilic progenitor cells (PMID 2990035). GM-CSF stimulates … WebThe new PVAX1-IRES-GM/B7.1 vector was successfully modified with the GM-CSF and B7.1 molecular adjuvants via IRES linking. 38 The use of IRESs enables vectors to … lcm of 120 and 72

Granulocyte Macrophage Colony Stimulating Factor

WebGranulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts. GM-CSF is a hematopoietic growth factor that stimulates the development of early erythroid megakaryocytic ... WebFeb 13, 2006 · It is secreted as a monomeric 23 kDa glycosylated small protein. Mature murine GM-CSF has 124 residues and human has 127 residues; both are derived from a precursor containing a signal peptide 6 ... WebRecombinant Mouse GM-CSF (Catalog # 415-ML) stimulates cell proliferation of the DA3 mouse myeloma cell line. The ED 50 for this effect is 5-30 pg/mL. SDS-PAGE View Larger 1 μg/lane of Recombinant Mouse GM-CSF was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa. lcm of 120 and 400

Mouse GM-CSF Recombinant Protein (PMC2011) - Thermo Fisher Scientific

Isosteviol Sodium (STVNA) Reduces Pro-Inflammatory …

WebDec 1, 1999 · Previously, the Ch14.18-GM-CSF fusion protein was found to bind purified G D2 antigen similarly as Ch14.18 but was five times less active than recombinant GM-CSF in stimulating the proliferation of GM-CSF-dependent cells . However, a more important question to answer is whether fusion of GM-CSF to mAb Ch14.18 interferes with the well … WebActive Recombinant mouse GM-CSF protein (Active) is a HEK 293 Full length protein 17 to 141 aa range animal free, >=95% purity, <= 0.005 Eu/µg endotoxin level and validated in FuncS, SDS-PAGE… Recombinant mouse GM-CSF protein (Active) (ab259385) … lcm of 12 10 15WebMay 4, 2024 · GM-CSF supports more myeloid progenitor cells, whereas IL-3 promotes more erythroid, megakaryocytic and multipotential progenitor cells. Their complementary in vivo biological effects and cross competition for receptor binding prompted the development of PIXY321, a synthetic hybrid protein of GM-CSF and IL-3. lcm of 120 and 300

"WebGM-CSF is a monomeric glycoprotein that functions as a cytokine —it is a white blood cell growth factor. [6] GM-CSF stimulates stem cells to produce granulocytes ( … " - Gm-csf protein

Gm-csf protein

Human GM-CSF Recombinant Protein (RGMCSF20) - Thermo Fisher Scientific

WebGM-CSF (Granulocyte-Macrophage colony-stimulating factor) is a 14.6kDa hematopoietic growth factor that exists in glycosylated and non-glycosylated biologically active … WebDisruption of GM-CSF signaling is also associated with marked downregulation of the expression of genes required for fatty acid metabolism including carnitine palmitoyltransferase 1 (CPT-1a), CPT-2, and fatty acid binding protein-1 (FABP-1), suggesting GM-CSF may be required for fatty acid metabolism in macrophages (Suzuki …

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WebGM-CSF/CSF2 Protein Overview. Colony-stimulating factors (CSFs) are proteins necessary for the survival, proliferation, and differentiation of hematopoietic progenitor cells. The CSF2 gene encodes … WebThis product is an active protein and may elicit a biological response in vivo, handle with caution. Reconstitution It is recommended to reconstitute the lyophilized product with …

WebAbstract. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pluripotent cytokine produced by many cells in the body, which regulates normal and malignant hemopoiesis as well as innate and adaptive immunity. GM-CSF assembles and activates its heterodimeric receptor complex on the surface of myeloid cells, initiating multiple ... WebGM-CSF is produced by a number of different cell types in response to cytokine or inflammatory stimuli. On mature hematopoietic cells, GM-CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages, and eosinophils. Recombinant mouse GM-CSF is a 14.0 kDa protein containing 125 amino acid residues.

WebThe human cDNA clones contained a single open-reading frame encoding a protein of 144 amino acids with a predicted molecular mass of 16,293 daltons and showed 69% nucleotide homology and 54% amino acid homology to mouse GM-CSF. One of these cDNA clones was shown to direct the synthesis of biologically active GM-CSF using a yeast … WebGM-CSF/CSF2 Protein Molecular Weight & PI Granulocyte-macrophage colony-stimulating factor precursor (GM-CSF) (Colony-stimulating factor) (CSF) (Molgramostin) (Sargramostim) Homo sapiens (Human). The …

WebActive Recombinant human GM-CSF protein (Active) is a HEK 293 Full length protein 18 to 144 aa range animal free, >=95% purity, <= 0.005 Eu/µg endotoxin level and validated in FuncS, SDS-PAGE…

WebG-CSF + GM-CSF: The addition of G-CSF to GM-CSF greatly increases the number of HSCs mobilized. The converse is not true. ... GM-CSF is a primarily T cell-derived 14-35 kDa variably glycosylated protein which affects growth and functions of granulocytes and cells of the macrophage lineage at all stages of maturation (Table 40.1). GM-CSF can be ... lcm of 12 15 20 54WebGranulocyte-macrophage colony-stimulating factor (GM-CSF) is a small glycoprotein growth factor which stimulates the production and function of neutrophils, eosinophils and monocytes. lcm of 12 18 27Webform of the GM-CSF protein is found extracellularly as a homodimer and the GM-CSF gene has been localized to a cluster of related genes at chromosome region 5q31, which is … lcm of 120 and 320WebGM-CSF: Products. GM-CSF (Granulocyte-Macrophage Colony Stimulating Factor) induces the development of monocytes, neutrophils, eosinophils, and myeloid and dermal dendritic cells. It also acts as a neutrophil and dendritic cell chemoattractant. GM-CSF promotes Th1 and Th17 cell mediated autoimmune inflammation as well as the … lcm of 12 16 and 36WebProduct Details Source Human GM-CSF, amino acids Ala18- Glu144 (Accession# NM_000758) was expressed in E. coli. Molecular Mass The 127 amino acid N-terminal methionylated recombinant protein has a predicted molecular mass of 14477.5 Da. lcm of 12 18 and 28WebSep 15, 2024 · This indicates that while ERK translocation might promote encephalitogenicity in T cells in vitro by facilitating GM-CSF production, this effect is overcome in more complex in vivo animal models of central nervous system (CNS) autoimmunity. ... Treating cells with either EPE or UO126 significantly decreased protein … lcm of 12 10 and 15WebMar 21, 2024 · GeneCards Summary for CSF2 Gene. CSF2 (Colony Stimulating Factor 2) is a Protein Coding gene. Diseases associated with CSF2 include Pulmonary Alveolar … lcm of 12 16 and 8