Mitf flybase
WebAchim A. Jungbluth, Klaus J. Busam, in Pathology of Melanocytic Tumors, 2024 MITF. Microphthalmia transcription factor (MITF) is a basic-loop-helix-loop leucine zipper (bHLH-Zip) transcription factor encoded by the MITF gene. 21 MITF is the human homologue of the mi gene in mice and can serve as an example how genetic research in mouse mutations … Web5 dec. 2024 · The clinical benefit of immune checkpoint inhibitory therapy (ICT) in advanced melanomas is limited by primary and acquired resistance. The molecular determinants of the resistance have been extensively studied, but these discoveries have not yet been translated into therapeutic benefits. As such, a paradigm shift in melanoma treatment, to …
Mitf flybase
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Web28 jan. 2024 · MITF belongs to the MiT family, gathering bHLH-LZ domain transcription factors (TFEB, TFEC and TFE3), that can homo- or hetero-dimerize to regulate gene … WebFlyBase Community Advisory Group; Recent Papers With Technical Advances; Gene Snapshots; FlyBase Forum; Newsletter; FlySlack Community; Twitter; NIH Funding; …
WebThe protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory ... WebFlyBase: a database for drosophila genetics and molecular biology FlyBase Gene Report: Dpse\Mitf EDRC 2024 Funding Opportunity for Outreach Efforts Get ready for Dros23! …
Web1 apr. 2024 · pH-controlled histone acetylation amplifies melanocyte differentiation downstream of MITF. Mitf-family transcription factor function is required within cranial neural crest cells to promote choroid fissure closure. Melanosome maturation proteins Oca2, Mitfa and Vps11 are differentially required for cisplatin resistance in zebrafish melanocytes. Web13 dec. 2024 · FlyBase Community Advisory Group; Recent Papers With Technical Advances; Gene Snapshots; FlyBase Forum; Newsletter; FlySlack Community; Twitter; …
Web10 dec. 2024 · In control flies, a mild (~1.75 fold) overexpression of Mitf mRNA resulted in a significant upregulation of 3 of the 7 Mitf targets tested (the vesicular ATPase (v-ATPase) …
Web15 feb. 2024 · FlyBase ID FBgn0086676 Gene Model Status Current Stock Availability 26 publicly available Gene Summary spinster ( spin) encodes a conserved transmembrane … free pictures of wagon wheelsWeb3 sep. 2024 · MITF is crucial for melanocyte development and differentiation, and has been termed a lineage-specific oncogene in melanoma. The three related proteins MITF, … farm fresh facebookWeb6 mrt. 2024 · Certain transcription factors have vital roles in lineage development, including specification of cell types and control of differentiation. Microphthalmia-associated transcription factor (MITF ... farm fresh facialWebThe mle gene (maleless; FBgn0002774), will be used as an example to demonstrate features of the data stored within the FlyBase gene reports.. Figure 2 shows the gene report page for mle.The top section, General Information, identifies the gene by symbol, name, and FlyBase unique identifier (FBgn0002774). The central section, Genomic Location, … free pictures of weddingWebMITF (microphthalmia-associated transcription factor) represents a melanocytic lineage-specific transcription factor whose role is profoundly extended in malignant melanoma. Over the last few years, the function of MITF has been tightly connected to plasticity of melanoma cells. MITF participates in … free pictures of waterfalls rainbowsWeb30 nov. 2014 · Introduction. Melanocytes are pigment-producing cells whose differentiation, proliferation and survival largely depend on MITF (microphthalmia-associated transcription factor), a melanocyte-specific transcription factor [for review 1, 2].Melanoma is a melanocyte-derived tumor in which MITF dependence is retained [for review 3]; thus, … free pictures of waterfallsWeb3 jan. 2024 · The control of MITF multiple pigments and associated differentiation genes strengthens the conviction that MITF functions as a central melanogenesis regulator. In melanocytes, the M promoter, which is closest to the particular downstream exons, is selected and is targeted at multiple transcriptional factors, including one cut domain2 … farm fresh facial mask