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WebIL-10 knockdown completely abolished the effect of TNA on microglial M2 polarization. Conclusion: Taken together, our data demonstrated that TNA attenuates neuronal loss in mouse TBI model and promotes M2 microglia by ERβ/IL-10 pathway. Thus, TNA could be a potential drug for TBI and/or the disorders that caused by microglial over-activation ... WebIL-10 knockdown completely abolished the effect of TNA on microglial M2 polarization. …
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